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A Study Identifies Seven Characteristics That Enhance the Probability of Death in Covid-19 Patients.


According to research published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer, the risk of death for patients with SARS-CoV-2 infection and thoracic cancer is determined by seven primary variables.

The researchers reviewed data from The Thoracic Cancers International COVID-19 Collaboration (TERAVOLT), a live global registry founded in March 2020 to better study the impact of COVID-19 infection on patients with thoracic malignancies in academic and community settings worldwide.

The project has been initiated by 114 centres in 19 countries, with 92 centres contributing data.
Patients with thoracic cancer (non-small cell lung cancer [NSCLC], small cell lung cancer, mesothelioma, thymic epithelial tumours, or other neuroendocrine tumours of pulmonary origin) who had a COVID-19 diagnosis of any of the following were eligible.

SARS-CoV-2 infection was either confirmed in the laboratory (using RT12 PCR/serology) or suspected based on radiological findings consistent with COVID-19 pneumonia and clinical symptoms (i.e., fever >37.5°C, cough, decrease in oxygen saturation of at least 5%, cough, diarrhoea, otitis, dysgeusia, myalgia, arthralgia, conjunctivitis, and rhinorrhea).


Along with reporting on morbidity and mortality, TERAVOLT aims to identify risk factors for poor outcomes, provide practitioners with real-time data on therapies that may affect COVID-19 survival, and assess long-term effects on care and delay in care for patients with curable and incurable thoracic malignancies.

The researchers had studied 1491 individuals from 18 countries as of April 15, 2021.
Cortellini and co-researchers recorded 361 incidents with a death rate of 24.2 percent for all causes.

After analysing more than 70 variables, the fast-backward step-down selection found seven key drivers of death:

“Despite continued efforts, such as vaccination campaigns and capacity expansion, SARS-CoV-2 will continue to have an effect on the continuity of treatment for cancer patients, at least to a certain level.
In response to the growing scenario, we developed a comprehensive and powerful prognostication system that doctors can employ “Alessio Cortellini, MD of Imperial College London in London, United Kingdom, stated.

“At the time of writing, this analysis did not examine the effect of COVD-19 vaccine.
The TERAVOLT database was recently upgraded to include information on vaccination status in addition to individual variant information.
With the additional data, a separate analysis will be conducted “Jennifer G Whisenant, Ph.D., of Vanderbilt University in Nashville, Tennessee, stated.






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