COVID- According to a review of US government data published Tuesday, 19 immunizations are unlikely to cause a rare inflammatory illness associated with coronavirus infection in children.
The condition, properly called multisystem inflammatory syndrome in children, is characterised by fever and symptoms involving at least two organs, which frequently include stomach pain, a rash, or bloodshot eyes. It is a rare complication in children who have received COVID-19 and occurs very rarely in adults. Although the illness frequently requires hospitalisation, the majority of people recover.
It was first discovered in the United Kingdom in early 2020 and is frequently confused with Kawasaki disease, which causes swelling and heart difficulties. According to the Centers for Disease Control and Prevention, more than 6,800 cases have been documented in the United States since February 2020.
The CDC and the US Food and Drug Administration placed the condition to a list of numerous potential adverse events of special interest as part of its COVID-19 vaccination safety monitoring. A few cases documented in people with no detectable coronavirus infection spurred the CDC and other researchers to conduct the new analysis, which was published Tuesday in the Lancet Child & Adolescent Health.
The notion that the vaccines caused the disorder is purely hypothetical, and the research revealed no evidence that they did, according to co-author Dr. Buddy Creech, a paediatric infectious disease specialist at Vanderbilt University who is directing a study of Moderna doses in infants.
“We don’t know how much the vaccine contributes to these problems,” Creech added. “Vaccination alone, in the absence of a previous infection, does not appear to be a significant trigger.”
The analysis used surveillance data from December 2020 to August 2021 for the first nine months of COVID-19 vaccination in the United States. During that time period, the FDA approved Pfizer’s COVID-19 shots for ages 16 and up; expanded that approval to include years 12 through 15 in May; and approved Moderna and Johnson & Johnson shots for ages 18 and up.
During that time period, about 21 million people aged 12 to 20 received at least one vaccine shot. Following that, twenty-one of them acquired the inflammatory illness. The study discovered that all had received Pfizer injections. Fifteen of the twenty-one individuals tested positive for a previous COVID-19 infection, which could have precipitated the disease.
The remaining six had no indication of prior infection, but the researchers cautioned that they could not conclusively rule out the possibility that they had never had COVID-19 or another infection that could have caused the inflammatory illness. Children with COVID-19 frequently exhibit no symptoms, and many are never evaluated.
The findings show that the inflammatory disease may occur in approximately one in every million children who have had COVID-19 and in approximately one in every three million children who have no detectable signs of previous COVID-19 infection following vaccination.
Although the majority of children who received COVID-19 do not experience post-infection sickness, it is expected to occur at a considerably greater rate than either of those post-vaccination rates. Between April and June 2020, the rate of unvaccinated infected people aged 12-20 in the United States was 200 cases per million.
“Their overall findings are quite comforting,” Dr. Mary Beth Son of Boston Children’s Hospital stated in an accompanying commentary to the study.
Dr. Adam Ratner, a pediatrician-scientist at New York University Langone Health, said the findings indicate that the chances of the shots eliciting an immune response that leads in the inflammatory illness are “very rare.” By contrast, there is compelling evidence that vaccination protects children from both COVID-19 and the disease, Ratner added.